Zebra

Zebra ZD421 Healthcare Thermal Printer 203dpi, 4.09in, 6ips, USB/Ethernet/Bluetooth LE, Medical-grade power supply

SKU: 

ZD4AH42-301E00EZ

Most desktop printers are built for general office labels, but the Zebra 421 is a 4-inch medical-grade thermal transfer printer designed for healthcare workflows that need reliable, easy-to-sanitize operation. With 203 dpi resolution, a 4.09-inch print width, and up to 6 ips print speed, it helps produce clear labels for patient IDs, specimens, prescriptions, and asset tracking while supporting secure, efficient use in clinical environments.
Description
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The Zebra ZD421T-HC Pro is a compact, healthcare-grade thermal transfer label printer engineered for clinical and point-of-care environments that demand clear, durable identification. Designed for bedside stations, laboratories, pharmacies and specimen-processing areas, this model combines a disinfectable housing and sealed controls with cartridge-based thermal transfer printing to produce consistent wristbands, specimen labels and medication tags. With high-contrast 203 x 203 DPI output, fast throughput and broad wired and wireless interfaces, the ZD421T-HC minimizes downtime, supports infection-control cleaning routines and integrates into hospital IT systems to help clinical teams maintain accuracy, traceability and operational efficiency.

Key Features

  • Healthcare-ready enclosure: Disinfectable, UV-resistant plastics and sealed buttons enable frequent cleaning and reduce infection-control risk in clinical settings.
  • Reliable thermal transfer printing: Cartridge-based thermal transfer delivers durable, long-lasting labels suitable for patient wristbands, specimens and medication labeling.
  • High legibility: 203 x 203 DPI resolution provides sharp text and barcode readability to support accurate patient identification and tracking.
  • Flexible connectivity: Multiple interfaces including USB, USB Host, Ethernet, Bluetooth (including BLE) and optional 802.11ac Wi‑Fi allow easy integration with clinical workstations and mobile devices.
  • Compact, serviceable design: Small desktop footprint with OpenACCESS media handling and status indicators simplifies media changes and routine operation in busy care areas.
  • Clinical workflow support: Built-in real time clock, reliable media sensors (black mark and gap) and compatibility with Zebra programming languages help ensure synchronized, accurate label production.

Specifications

  • Brand: Zebra
  • Product Name: Zebra ZD421T-HC Pro
  • Print Technology: Thermal transfer (cartridge)
  • Print Resolution: 203 x 203 DPI
  • Maximum Print Speed: 152 mm/sec (6 ips)
  • Maximum Print Width: 104 mm
  • Maximum Label Width: 108 mm
  • Maximum Label Length: 0.991 m
  • Maximum Roll Diameter: 127 mm
  • Media Thickness: 0.08 - 0.19 mm
  • Connectivity / Interfaces: USB 2.0, USB Host, Ethernet; optional Serial; 802.11ac Wi‑Fi (variant dependent); Bluetooth 4.1 / Bluetooth 5.0 with BLE
  • Bluetooth Version: 5.0
  • Bluetooth Low Energy (BLE): Yes
  • Wi‑Fi: 802.11ac (variant dependent)
  • Display: LCD (built-in)
  • Real Time Clock (RTC): Yes
  • Sensors: Black mark sensor, Gap sensor (full-width movable reflective & multi-position transmissive options)
  • Internal Memory (RAM): 256 MB
  • Flash Memory: 512 MB
  • Programming Languages: ZPL II, EPL2, XML, ZBI, PDF Direct
  • Dimensions (W x D x H): 202 x 254 x 177 mm
  • Weight: 2.3 kg
  • Operating Temperature: 4.4 - 41 °C
  • Storage Temperature: -40 - 60 °C
  • Operating Relative Humidity: 10 - 90%
  • Storage Relative Humidity: 5 - 95%
  • AC Input Voltage: 100 - 240 V
  • AC Input Frequency: 50 - 60 Hz
  • Power Supply Compliance: IEC 60601-1 (medical-grade where specified)
  • Disinfectable Housing: Yes
  • USB 2.0 Ports Quantity: 1
  • ENERGY STAR Certified: Yes (variant dependent)

Main Features

  • Rugged: Commercial

  • POS: Yes

  • Print Speed: 6 in/s

  • Equipment Format: Desktop

  • DPI: 203 dpi

  • Connection: USB, Ethernet, Bluetooth

  • Max Width: 4 mm

  • Printing Technology: Thermal Transfer

Technical Specifications
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Technical Information
Recommended Use Label/Receipt Print
Print Color Capability Monochrome
Maximum Mono Print Speed 5.98 in/s
Maximum Print Resolution (dpi) 203
Maximum Print Width 4.09"
Real Time Clock Yes
Application/Usage Desktop
Features
  • Status Indicator
  • Dual Wall Frame
Mobile Device Printing Yes
Print Technology Thermal Transfer
Memory
Standard Memory 256 MB
Interfaces/Ports
USB Host Yes
USB Yes
Network & Communication
Ethernet Yes
Bluetooth Yes
Near Field Communication (NFC) Yes
Media Types & Handling
Media Type
  • Receipt
  • Label
  • Reflective
  • Black Mark
  • Gap
  • Roll Fed
  • Fanfold
  • Die-cut Label
  • Continuous Label
  • Tag Stock
  • Continuous Receipt
  • Wristband
Maximum Roll Diameter 5"
Maximum Label Width 4.41"
Maximum Label Length 39.02"
Fonts & Emulation
Language Emulation
  • ZPL
  • EPL
  • ZPL II
  • EPL2
  • XML
  • ZBI
Power Description
Power Source AC Supply
Physical Characteristics
Form Factor Portable
Height 7.4"
Width 8"
Depth 10.5"
Weight (Approximate) 4.52 lb
Miscellaneous
Power Cable Localization US
Package Contents
  • ZD421-HC Thermal Transfer Printer
  • AC Power Supply
  • Power Cord(s)
  • USB Cable
  • Quick Start Guide
  • Regulatory Guide
Cables Included
  • USB
  • AC
Platform Supported
  • iOS
  • Android
  • PC
Certifications & Standards
  • cTUVus
  • Energy Star Yes
    Environmentally Friendly Yes
    Environmental Compliance Restriction of Hazardous Substances (RoHS)
    Warranty
    Limited Warranty 2 Year
    Documents
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    Product document zd421-hc.pdf ZD4AH42-301E00EZ Product document mod-zd421t-hc-zebra-label-printer-datasheet.pdf MOD-ZD421T-HC