Zebra

Zebra ZD421 Healthcare label printer 203dpi, Direct Thermal, BTLE 5, Ethernet

SKU: 

ZD4AH42-D01E00EZ

Zebra ZD421 Healthcare is a direct thermal desktop label printer built for healthcare workflows, with 203 dpi resolution and an all-in-one design for reliable label production. It supports USB 2.0, USB Host, Ethernet, and BTLE 5, making it easy to connect for prescription labels, specimen labels, patient ID wristbands, and other clinical labeling tasks.
Description
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The Zebra ZD421D is a healthcare-focused direct thermal desktop label printer engineered for clinical and laboratory workflows that demand hygiene, accuracy and reliable on‑demand output. Designed for hospitals, clinics, pharmacies and diagnostic labs, the device prints wristbands, specimen and medication labels without ribbons, reducing consumable handling and maintenance. Its disinfectant‑ready, UV‑resistant housing with a sealed key interface supports frequent cleaning and infection‑control routines, while compact dimensions, fast print performance and broad connectivity options help integrate the printer at bedside stations, registration desks and workbenches for consistent, professional labeling across patient care and specimen-tracking applications.

Key Features

  • Healthcare-ready construction: Disinfectant-ready, UV-resistant housing and sealed button/interface minimize crevices and support regular cleaning for infection control.
  • Direct thermal operation: Ribbon-free printing simplifies maintenance and consumables management for short-run, on-demand label tasks common in clinical settings.
  • Flexible connectivity: Multiple wired and wireless options—USB, USB Host, Ethernet, Bluetooth Low Energy (BLE/BTLE) and Wi‑Fi (SKU dependent)—enable easy integration into point-of-care and networked environments.
  • Selectable resolution and speed: Available 203 dpi (with optional 300 dpi on select SKUs) and high desktop print speeds (up to 152 mm/s / approximately 6 ips) deliver legible barcodes and responsive output.
  • Reliable media handling: Supports black mark and gap sensing plus a range of media types and roll sizes for labels, receipts and wristbands to reduce jams and misfeeds.

Specifications

  • Brand: Zebra
  • Product Name: Zebra ZD421D (ZD421 family)
  • Product Family: ZD421
  • Printing Technology: Direct thermal
  • Print Resolution: 203 dpi (optional 300 dpi on select SKUs)
  • Resolution (dots per mm): 8 dots/mm (203 dpi) and up to 12 dots/mm (300 dpi SKUs)
  • Maximum Print Speed: Up to 152 mm/s (approximately 6 ips)
  • Maximum Print Width: 104 mm (≈4.09 in) / example maximum print width shown 4.27 in on some SKUs
  • Maximum Media Width: 108 mm
  • Maximum Roll Diameter: 127 mm (5 in on some SKUs)
  • Connectivity: USB, USB Host, Ethernet, Bluetooth Low Energy (BLE/BTLE/BT 5.x), Wi‑Fi (802.11ax on select SKUs)
  • Flash Memory: 512 MB
  • RAM / SDRAM: 256 MB
  • Real Time Clock: Available on supported SKUs
  • Sensors: Black mark sensor, gap sensor (full-width/moveable sensors on some SKUs)
  • Housing Features: Disinfectant-ready, UV-resistant, sealed key interface
  • Power Supply Compliance: IEC 60601-1 (medical-grade compliance noted on some SKUs)
  • Supported Media Types: Labels, receipts, wristbands and other roll-fed/continuous formats (SKU dependent)
  • Target Industry: Healthcare
  • Warranty: 36 months (as specified for select configurations)

Main Features

  • Rugged: Commercial

  • POS: Yes

  • Print Speed: 6 in/s

  • Equipment Format: Desktop

  • DPI: 203 dpi

  • Connection: USB, Ethernet, Bluetooth

  • Max Width: 4 mm

  • Printing Technology: Direct Thermal

Technical Specifications
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Technical Information
Recommended Use Label/Receipt Print
Print Color Capability Monochrome
Maximum Mono Print Speed 5.98 in/s
Maximum Print Resolution (dpi) 203
Maximum Print Width 4.09"
Real Time Clock Yes
Application/Usage Desktop
Features
  • Status Indicator
  • Dual Wall Frame
Mobile Device Printing Yes
Print Technology Direct Thermal
Memory
Standard Memory 256 MB
Interfaces/Ports
USB Host Yes
USB Yes
Network & Communication
Ethernet Yes
Bluetooth Yes
Near Field Communication (NFC) Yes
Media Types & Handling
Media Type
  • Receipt
  • Label
  • Reflective
  • Black Mark
  • Gap
  • Roll Fed
  • Fanfold
  • Die-cut Label
  • Continuous Label
  • Tag Stock
  • Continuous Receipt
  • Wristband
Maximum Roll Diameter 5"
Maximum Label Width 4.25"
Maximum Label Length 39.02"
Fonts & Emulation
Language Emulation
  • ZPL
  • EPL
  • ZPL II
  • EPL2
  • XML
  • ZBI
Power Description
Power Source AC Supply
Physical Characteristics
Form Factor Portable
Height 5.9"
Width 7"
Depth 8.7"
Weight (Approximate) 2.98 lb
Miscellaneous
Power Cable Localization US
Package Contents
  • ZD421-HC Direct Thermal Printer
  • AC Power Supply
  • Power Cord(s)
  • USB Cable
  • Quick Start Guide
  • Regulatory Guide
Cables Included
  • USB
  • AC
Platform Supported
  • iOS
  • Android
  • PC
Certifications & Standards
  • cTUVus
  • Energy Star Yes
    Environmentally Friendly Yes
    Environmental Compliance Restriction of Hazardous Substances (RoHS)
    Warranty
    Limited Warranty 2 Year
    Documents
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    Product document zd421-hc.pdf ZD4AH42-D01E00EZ Product document zd421-hc-spec-sheet-en-us.pdf MOD-ZD421D-HC